General Info

[ExpatLover]

I actually agree with a lot of this although I am less pessimist about vaccines. Lockdown efficiency, well that can buy some time in certain locations (AUS, NZ), but globally that ship has sailed. How is it that we don't hear of outbreaks in China?

Man you paint a dark future here.

In China, life is back to normal since June. Everything is under control, here the vaccination is not possible if you are above 59, the contrary from the rest of the world. Free vaccination everywhere but not enough candidats, but there is no stress on it. I wrote it many times the super power today is not the US but China and they are clever enough to keep very modest.

[Downandup]

Problem is that even if deaths so far have been few, far more have shown dangerously extreme amounts of white blood cells following the vaccines. 2.8% are showing these extreme numbers. While 8%+ are showing less increases, but still some increase. Which may cause problems long term.

I have not heard anything about this, the closest I've come to is that there is an elevated wbc count when fighting covid, the same as any other infection. Can you provide some credible citations for this?

[PaulInZurich]

Europe faced several medical scandals in the last 40 years, and trust is something that the people in responsibility have to win, it is not granted. Most of the people just want to get back the life from before, and the politicians make them thing that this will be possible if they get vaccinated and follow strictly the stupid rules of the different useless lockdown. And what if the vaccine are not efficient enough, if we need to get revaccinated every 6 months (hypothesis on the table in Israel), today he situation is worse that I ever expected, just check what was promised by the leaders 6 months back, and where we are today. There is a possibility that the life from 2019 will not come back before 10 or 20 years may be never. The situation is critical in 2 big countries Brazil and India what will happen there in the coming months will be very important for the rest of the world, many new variants can pop up and the vaccines could also face big efficiency issues to fight those variants.

I actually agree with a lot of this although I am less pessimist about vaccines. Lockdown efficiency, well that can buy some time in certain locations (AUS, NZ), but globally that ship has sailed. How is it that we don't hear of outbreaks in China?

Man you paint a dark future here.

[ExpatLover]

I don't think that Remdisivir can cause resisist covid because it stops replication and therefore would lessen the chance of resistance.

It is not what some top medical teams are saying, just have for example a look on the publications of the IHU.

[Mursenary]

Pfizer now say for third dose and yearly dose for mutants, they will make good business. I m afraid sad times to come, when UK mutant killed a lot since beginning of the year, but I m afraid south African and Brazilian may also kill a lot in EU, when killed in Summer in Brazil. High vaccine rate in UK, but still restrictions and also for so important today.

Good thing I'm not scared of the vaccine-induced third testicle. Give me that 3rd shot baby. And 4th. And 5th!

Regardless, newest research still suggests that your fears of efficacy can be put on hold.

http://www.internationalsexguide.nl/...57#post2551957

[Sirioja]

Time to incorporate new data. Form new opinions.

Offers protection against British, South African, and Brazilian variants and greater Antibody levels to them than with natural immunity.

Reduces spread:Good one dose efficacy and reduced spread. Needs peer review:

Pfizer now say for third dose and yearly dose for mutants, they will make good business. I m afraid sad times to come, when UK mutant killed a lot since beginning of the year, but I m afraid south African and Brazilian may also kill a lot in EU, when killed in Summer in Brazil. High vaccine rate in UK, but still restrictions and also for so important today.

[Pistons]

. But the clinical picture in that scenario is not consistent with vaccine side effects.

Do you wannabe?

[DrPoon]

You should look about what is happening now in India, second largest population in the world, they use a lot of Remdisivir which is a terrible medicine creating a lot of variants. I don t believe this will not impact negatively the covid situation in the world.

I don't think that Remdisivir can cause resisist covid because it stops replication and therefore would lessen the chance of resistance.

[Mursenary]

Once again you're making up the figures.

Well, not to mention that elevated WBCs / leukocytes itself doesn't actually directly cause many problems. It's just the result of either inflammation or leukemia if cells are immature, and used as an indicator of other processes, but rarely ever the cause.

All it means is that you have a high number of granulocytes, monocytes, and to a lesser degree, a corresponding increase in B_and_T lymphocytes.

Basically, if WBCs are elevated, we already know what we need to know. How much it's elevated is not all that useful. In conditions such leukemia, when immature cells are massively released into the bloodstream, then it may lead to a hyper-viscosity syndrome. But the clinical picture in that scenario is not consistent with vaccine side effects.

[Mursenary]

Vaccine should help not to be heavily sick, but not even sure for South African and Brazilian which are now in EU. But our doctors advice to keep on mask, even after vaccine which can't help spreading. Italy opened and closed, same for Ontario, Japan tried and under restrictions again, and without needing our new more killer mutants.

Time to incorporate new data. Form new opinions.

Offers protection against British, South African, and Brazilian variants and greater Antibody levels to them than with natural immunity.

Preliminary evidence suggests that the currently authorized COVID-19 vaccines may provide some protection against a variety of strains, including B.1.1.7 (originally identified in the United Kingdom). Reduced antibody neutralization and efficacy have been observed for the B.1.351 strain (originally identified in South Africa). However, across studies, antibody neutralizing activity of sera from vaccinated people was still generally higher than that observed for convalescent sera from people who have recovered from COVID-19.
A growing body of evidence suggests that fully vaccinated people are less likely to have asymptomatic infection and potentially less likely to transmit SARS-CoV-2 to others. However, further investigation is ongoin

https://www.cdc.gov/coronavirus/2019...ed-people.html

Many of the vaccine efficacy studies were carried out before the emergence of SARS-CoV-2 VOCs. In studies that address the variants, there is limited preliminary evidence of reduced vaccine efficacy, in particular for B.1.351 and possibly also for P.1.

https://www.ecdc.europa.eu/en/public...ious-infection

Reduces spread:

The new study, by researchers at the C.D.C., suggested that since infections were so rare, transmission was likely rare, too.

https://www.nytimes.com/2021/03/29/w...infection.html

If you cant get infected, you cant infect anyone else, which means the vaccines can reduce transmission as well as the disease, says Marm Kilpatrick, an infectious diseases researcher at the University of California, Santa Cruz, who was not involved in the study.

https://www.sciencenews.org/article/...ission-disease

Recent results from real-world studies show the COVID-19 vaccines protect against asymptomatic infection, suggesting they also drastically reduce virus transmission

https://www.usatoday.com/story/news/...ay/4833945001/

Good one dose efficacy and reduced spread. Needs peer review:

Pfizer COVID-19 vaccine reduces transmission after one dose - UK study
https://www.reuters.com/article/uk-h...-idUSKBN2AQ1A7

[BigBuddy69]

Problem is that even if deaths so far have been few, far more have shown dangerously extreme amounts of white blood cells following the vaccines. 2.8% are showing these extreme numbers. While 8%+ are showing less increases, but still some increase. Which may cause problems long term.

Once again you're making up the figures.

[Pistons]

That is from the AZ vaccine. Not from covid.

[Pistons]

When you listen to the experts they repeatedly say that vaccines are not the complete answer. They are very effective in reducing transmission and severity in the general population, enough to reduce the restrictions as the most vulnerable are immunised. The EU is overreacting to the incredibly few incidents of CVST in the 100 millions vaccinated and are ignoring the fact that there are 8 - 10 times as many incidents of CVST amongst those infected with Covid. Rare reactions like these happen with any vaccine but this time it is being subject to worldwide scruitiny where perfection is demanded.

Problem is that even if deaths so far have been few, far more have shown dangerously extreme amounts of white blood cells following the vaccines. 2.8% are showing these extreme numbers. While 8%+ are showing less increases, but still some increase. Which may cause problems long term.

[ExpatLover]

When you listen to the experts they repeatedly say that vaccines are not the complete answer. They are very effective in reducing transmission and severity in the general population, enough to reduce the restrictions as the most vulnerable are immunised. The EU is overreacting to the incredibly few incidents of CVST in the 100 millions vaccinated and are ignoring the fact that there are 8 - 10 times as many incidents of CVST amongst those infected with Covid. Rare reactions like these happen with any vaccine but this time it is being subject to worldwide scruitiny where perfection is demanded.

Europe faced several medical scandals in the last 40 years, and trust is something that the people in responsibility have to win, it is not granted. Most of the people just want to get back the life from before, and the politicians make them thing that this will be possible if they get vaccinated and follow strictly the stupid rules of the different useless lockdown. And what if the vaccine are not efficient enough, if we need to get revaccinated every 6 months (hypothesis on the table in Israel), today he situation is worse that I ever expected, just check what was promised by the leaders 6 months back, and where we are today. There is a possibility that the life from 2019 will not come back before 10 or 20 years may be never. The situation is critical in 2 big countries Brazil and India what will happen there in the coming months will be very important for the rest of the world, many new variants can pop up and the vaccines could also face big efficiency issues to fight those variants.

[PaulInZurich]

When you listen to the experts they repeatedly say that vaccines are not the complete answer. They are very effective in reducing transmission and severity in the general population, enough to reduce the restrictions as the most vulnerable are immunised. The EU is overreacting to the incredibly few incidents of CVST in the 100 millions vaccinated and are ignoring the fact that there are 8 - 10 times as many incidents of CVST amongst those infected with Covid. Rare reactions like these happen with any vaccine but this time it is being subject to worldwide scruitiny where perfection is demanded.

Similar opinion here. I hope that once most vulnerable population (let's say over 65, plus people with chronic diseases) are vaccinated, that should reflect in number of people in hospitals + number of deaths. Then lifting of restrictions could follow. I would expect travel restrictions to stay in place for countries with high numbers.

The reaction to AZ and J&J is in the area damned if you, damned if you don't. The headlines would be "They are hiding things from us. Why are they not taking this seriously?" I don't know what would be more damaging.