Sosua Reports

[QUOTE=CharlesPooter;1726578]Not referring to Elevex in particular, but a doctor told me we should be wary of cutting pills unless they have a division scored at manufacture. The reason is that unscored pills (intended by the manufacturers to be taken whole) may not have the active ingredients evenly distributed throughout the pill. You might therefore receive an unexpectedly stronger or weaker dose by using only half of such a pill.[/QUOTE]You are partly right, but the ingredients are thoroughly mixed before a pill is formed by pressing in a mold. The uneven distribution occurs if the cutline is not accurate, so for example a nurse in a hospital may not cut an unscored pill as the is no way to be sure of the exact dose the patient will receive, especially if it crumbles on cutting. The idea that there is some machine that can redistribute ingredients after a pill is formed is bizarre. Show me a URL from an authoritative source that explains this magic.

[QUOTE=MrGogo;1726259]I've been looking for consumer reports on this generic cialis, and can't find any. Has anyone had personal experience using Mamba? Do you take the whole tablet or just half? What dude effects have you had?

Also the 20 MG cialis tablet, do you split it or take whole? Any help would be appreciated.[/QUOTE]Manga 36 is my go to pill when I am in Sosua. I still have three left because I load up on them. Even a half of one and I can ride for a day and a half. I've never had a side effect that I've notice

[QUOTE=SavePros321;1726957]Hey BO, what would be considered an "unscored pill"? I usually take my 20 MG Cialis (real, not generic) and split it into two. Are they not meant to be split?[/QUOTE]A pill like the one in the picture is meant to be split and has an uniform active ingredient distribution. If it has no line then it is highly probable than dosage is going to have a wide variation between halves.

[QUOTE=Frannie;1727109]. The idea that there is some machine that can redistribute ingredients after a pill is formed is bizarre. Show me a URL from an authoritative source that explains this magic.[/QUOTE]I worked as a plant accountant in a pharm plant and was in charge of accounting for property, plant and equipment. Believe me, there is equipment for almost everything in the production process, for dosage homogenization to ingredient detection / removal, detectors, coaters and others. And the cheapest of these machines cost a few millions. Pills were sampled in our labs for dosage distribution and functionality and dosage correctness and validation as required by federal laws.

[QUOTE=BoricuaOnline;1727134]I worked as a plant accountant in a pharm plant and was in charge of accounting for property, plant and equipment. Believe me, there is equipment for almost everything in the production process, for dosage homogenization to ingredient detection / removal, detectors, coaters and others. And the cheapest of these machines cost a few millions. Pills were sampled in our labs for dosage distribution and functionality and dosage correctness and validation as required by federal laws.[/QUOTE]That might be the case if you are talking about a pill or more likely a capsule that contains a combination of 2 drugs, because the two drugs have to be combined or fused in some way at the point of making the pill, so obviously splitting that apart would created dosage control problems. However where single drug pills (not capsules) are manufactured, the mixing all takes place before the dried powder is pressed into pills and coated by the machines of which you speak. If what you say is the case for single drug pills, then potentially a tablet of 100 mgs of Viagra might have 75 mgs in one end and 25 mgs in the other end, so the total variance for that pill might be anything between 150 mgs and 50 mgs, which is obviously not satisfactory or safe by any standards. But it doesn't work that way, regardless of what you may have been told by production workers at the factory where you worked. They may not have understood the whole process themselves.

Also, although the machines used by multinational companies may indeed cost millions of dollars, machines that can perform basic pill making are available for $1000 or less, and in fact this link shows a small capsule making machine for less than $200.

http://www.ebay.com/bhp/pill-making-machine


Obviously these are not a high capacity computerized machine capable of turning out millions of capsules per week, but then making sildenafil tablets like Viagra is not a massively technically complex process and in third world countries is likely to be done much more cheaply and using older technologies than using a sunk cost of millions of dollars on equipment. After all, look how relatively effective medical practice is in the DR using mostly very cheap and portable sonography in place of incredibly expensive MRI'S. Obviously there is some loss of function using an older technology that costs much, much less, but it is surprisingly effective, and when they diagnosed a cyst at the back of my knee in Puerto Plata, I was surprised how clear the sonogram pictures were. for something that cost $20 rather than $2000.

[QUOTE=Frannie;1727323]That might be the case if you are talking about a pill or more likely a capsule that contains a combination of 2 drugs, because the two drugs have to be combined or fused in some way at the point of making the pill, so obviously splitting that apart would created dosage control problems. However where single drug pills (not capsules) are manufactured, the mixing all takes place before the dried powder is pressed into pills and coated by the machines of which you speak. .[/QUOTE]C'mon. Frannie.

We all know that a drug doesn't comprise 100% of the pill. There are coatings, additives, coloring, all kinds of fillers and agents to make the it more benign and absorbable.

That's why they market so many varieties of the common generic drugs.

[QUOTE=Oakie;1727344]C'mon. Frannie.

We all know that a drug doesn't comprise 100% of the pill. There are coatings, additives, coloring, all kinds of fillers and agents to make the it more benign and absorbable.

That's why they market so many varieties of the common generic drugs.[/QUOTE]Yes, there are fillers and so on, but the whole brew is mixed before the pills are pressed, so as to make the contents of one pill the same as another. How could you possible design the brew so that if one end of a 100 mgs pill had 25 mgs of active ingredient, the other end would automatically have 75 mgs. It makes no sense. It is like saying that you have to drink the whole glass of Cuba libre, because some of the alcohol might have evaporated from the top.

[QUOTE=Frannie;1727396]Yes, there are fillers and so on, but the whole brew is mixed before the pills are pressed, so as to make the contents of one pill the same as another. How could you possible design the brew so that if one end of a 100 mgs pill had 25 mgs of active ingredient, the other end would automatically have 75 mgs. It makes no sense. It is like saying that you have to drink the whole glass of Cuba libre, because some of the alcohol might have evaporated from the top.[/QUOTE]Your Cuba libre is a good example. Depending on how it is poured, without mixing, the ingredients tend to be stratified. Without any mixing, if you drink the top half, you will get a different amount of the active ingredient, than if you drink the bottom half. Even with a quick stir, the distribution isn't perfect, but if you are drinking the entire drink it doesn't matter.

Tablets that are intended to be split, go through an additional homogenization step to ensure the mix is complete.

This is why Bond always orders his vodka martinis "shaken, not stirred", because he knows some villain will interrupt him halfway through the drink.

[QUOTE=Frannie;1727396]Yes, there are fillers and so on, but the whole brew is mixed before the pills are pressed, so as to make the contents of one pill the same as another. How could you possible design the brew so that if one end of a 100 mgs pill had 25 mgs of active ingredient, the other end would automatically have 75 mgs. It makes no sense. It is like saying that you have to drink the whole glass of Cuba libre, because some of the alcohol might have evaporated from the top.[/QUOTE]If people are confident that a dosage is exactly what they want, it makes sense to avoid things like pill cutting if possible simply because it messes with what works and introduces pointless variability. Otherwise, dosages are most often extremely sloppy aproximations. The very idea of having a couple standard size pills for people who vary a lot in mass and metabolism suggests this. Company's create dosages for marketing reasons as much as medical, often creating significant price differences that lead people to buy the large economy size pill and cut it. Neither the whole pill or the cut pill is known to a "correct" dose. Often the only real knowns are what's minimally effective and what's often toxic.

[QUOTE=Frannie;1727396] It is like saying that you have to drink the whole glass of Cuba libre, because some of the alcohol might have evaporated from the top.[/QUOTE]That's exactly what I m saying.

A Cuba Libre's strength depends on whether it is drunk before the all the ice melts.

Anyway, how the hell are ya?

Does anybody have any knew information on the ground?

[QUOTE=Camaro1257;1727522]Does anybody have any knew information on the ground?[/QUOTE]That is an excellent question!

[QUOTE=Frannie;1727323]. But it doesn't work that way, regardless of what you may have been told by production workers at the factory where you worked. They may not have understood the whole process themselves.

.[/QUOTE]Hi Frannie, good evening. As a manufacturing plant employee we were required by US federal agencies to take a yearly training called good manufacturing practices (GMP's). I get my knowledge from these trainings. As far as I remember scored pills that have an uniform design are meant to be slipt in halves. Uneven designed pills and unscored pills are meant to be consumed as a whole.

I remember the cost of a 5 gallon of an active ingredient for a pill we manufacture was $125,000. Each pill got a traces if these ingredient so to homogenize these traces between a pill we have to use a highly and frequently calibrated and validated equipment. Most times the active ingredient represents a small percentage of the pill total.

[QUOTE=Camaro1257;1727522]Does anybody have any knew information on the ground?[/QUOTE]In Sosua there are 500 girls tonight and zero guys. They are all splitting pills. Girls came in different dosages. They are not meant to be split. Do they?

[QUOTE=BoricuaOnline;1727535]In Sosua there are 500 girls tonight and zero guys. They are all splitting pills. Girls came in different dosages. They are not meant to be split. Do they?[/QUOTE]LOL.

Get back to mongering. No more discussion about pills.