Re: Purposeful Manipulation and Chinese Tech
[QUOTE=McAdonis;2563217]The way I interpret the below (removed middle part for sake of brevity): virologists do not yet possess the skill to develop a virulent virus from scratch; they can only take an already virulent virus and make minor tweaks to it. But SARS-CoV-2 does not closely resemble anything they have seen before. Is this not the general negative opinion many hold of Chinese? They cannot develop anything themselves, they only know how to steal technology and make minor tweaks.
The devious ching-chongs could have randomly manipulated the genetic material, trying different combinations until they got lucky. I have no idea what kind of brute force effort or luck would be required. Would it be similar to digital encryption where it would take the fastest supercomputer a million years to crack 256-bit AES encryption?
I will leave the leading questions and cross-examination of witnesses to someone like yourself, who is clever enough to think six moves ahead.[/QUOTE]The second half of the passage ignores one thing: The Shotgun Approach.
I've been out of the lab for over 10 years so am not up to date on the minutia of the current tech, but even back then, if you wanted to create a complimentary protein that binds to a receptor, it could be done by sequencing the amino acid chain with a specific region that has affinity for the receptor. While predicting how an amino acid chain would fold into its final protein form is quite a challenge, you would not have to do it with precision. Instead, you create numerous candidate amino acid chains containing that specific region, then you isolate the ones with affinity to the receptor using various methods such as tagging it with a fluorescent antibody. Once isolated, you just reverse sequence the corresponding DNA / rna sequence and insert it in your new virus using the most appropriate delivery vector for that virus. The rest is just the nuts and bolts of ensuring that your new virus expresses the protein. That's the theory anyway.
Anyway, the Chinese have the resources. Most state universities with a top tier microbiology department do. I just question why the Chinese would purposefully unleash a plan like that. Considering their new found formidable yet insecure position on the world stage, they had too much to lose to risk such a devious plan.
As for type of research they might have been conducting, all sorts of reasons exists. Outside of purposefully engineering a bioweapon, it could have even been an altruistic venture such as creating an inert protein that neutralizes the pathogenicity of a future SARS virus. After all, that region of the world have been dealing those types of endemics for quite a while, which each new strain having the potential for more severe disease. At any step leading to a final product, there could have been all sorts of steps from original virus to a final beneficial strand with intermediaries having unintended pathogenic properties. Such is the process of scientific development that the general public does not consider. It's sexier to go straight to the narrative of good versus evil, us versus them, rather than chalking things up to mere incompetence.
It's human nature to believe there is a plan devised by a more powerful authority. In a way it gives them comfort. It's much scarier for people to think that we are floating around with no plan or purpose. It's the basis of religion. Most people don't want to believe that they are insignificant.